The Heterogeneity of Autism: The Need to Consider Subtypes for Research
In this cutting-edge session, leading researcher (and mother of an autistic adult) Dr. Valerie Hu shares her life-long research on subtypes of autism. As one of the leading researchers on these topics, this session will certainly provide new insight and deeper understanding about autism for even the most well-versed in the field, while also giving those new to autism some useful explanations and insights about key differences that are present across the spectrum.
Related Articles & Further Reading
Genome-wide identification of transcriptional targets of RORA reveals direct regulation of multiple genes associated with autism spectrum disorder; Sarachana and Hu Molecular Autism 2013, 4:14
Novel clustering of items from the Autism Diagnostic Interview-Revised to define phenotypes within autism spectrum disorders; Valerie W. Hu and Mara E. Steinberg, Autism Res. 2009 April; 2(2): 67–77.
Gene Expression Profiling Differentiates Autism Case–Controls and Phenotypic Variants of Autism Spectrum Disorders: Evidence for Circadian Rhythm Dysfunction in Severe Autism; Valerie W. Hu, Tewarit Sarachana, Kyung Soon Kim, AnhThu Nguyen, Shreya Kulkarni, Mara E. Steinberg, Truong Luu, Yinglei Lai, and Norman H. Lee, Autism Res. 2009 Apr; 2(2): 78–97.
Novel Autism Subtype-Dependent Genetic Variants Are Revealed by Quantitative Trait and Subphenotype Association Analyses of Published GWAS Data; Valerie W. Hu, Anjene Addington, and Alexander Hyman, PLoS One. 2011; 6(4): e19067
ASD Phenotype—Genotype Associations in Concordant and Discordant Monozygotic and Dizygotic Twins Stratified by Severity of Autistic Traits; Valerie W. Hu, Christine A. Devlin, and Jessica J. Debski, Int J Mol Sci. 2019 Aug; 20(15): 3804
Phenotypic Subtyping and Re-analyses of Existing Transcriptomic Data from Autistic Probands in Simplex Families Reveal Differentially Expressed and ASD Trait-Associated Genes; Valerie W. Hu * and Chongfeng Bi, Front Neurol. 2020; 11: 578972.
Phenotypic Subtyping and Re-Analysis of Existing Methylation Data from Autistic Probands in Simplex Families Reveal ASD Subtype-Associated Differentially Methylated Genes and Biological Functions; Elizabeth C. Lee and Valerie W. Hu; Int J Mol Sci. 2020 Sep; 21(18)
Developing a Predictive Gene Classifier for Autism Spectrum Disorders Based upon Differential Gene Expression Profiles of Phenotypic Subgroups; Valerie W. Hu, Ph.D. and Yinglei Lai, Ph.D.; N Am J Med Sci (Boston). 2013; 6(3) Reviews
Subphenotype-Dependent Disease Markers for Diagnosis and Personalized Treatment of Autism Spectrum Disorders; Valerie W. Hu, Dis Markers. 2012; 33(5): 277–288
From Genes to Environment: Using integrative genomics to build a “systems level” understanding of autism spectrum disorders, Valerie W. Hu, Ph.D., Child Dev. 2013 January; 84(1): 89–103
The expanding genomic landscape of autism: discovering the ‘forest’ beyond the ‘trees’; Valerie W Hu, Future Neurol. 2013 Jan 1; 8(1): 29–42.
